250mg Triclabendazole Bolus
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Pharmacological Actions
Pharmacodynamics Triclobendazole ndeye benzimidazole kirasi yemishonga, inonyanya kushandiswa kurwisa Fasciola hepatica, uye ine kuuraya kuri pachena mhedzisiro paFasciola hepatica yemazera akasiyana.mushonga wefluke.Mushure mokunge mushonga wacho wabatwa, unokanganisa maitiro e microtubule uye kushanda kweparasite, Inodzivisa kusunungurwa kweparasite hydrolytic proteases.Mhedzisiro yetriclobendazole pahonye inosiyana nekuisa pfungwa, senge vanhu vakuru pane yakaderera concentration (1 ~ 3μg/ml)
Mushonga wacho uchiri kurarama kwemaawa makumi maviri nemana, uye basa racho rakanyanya kuderera muhuwandu hwepamusoro (10-25μg / ml) kwemaawa makumi maviri nemana;iyo yakakwirira ye 25-50μg / ml inodzivisa zvachose kwemaawa makumi maviri nemana.Asi zvakanyanya kunzwa kune makonye.Pa10 μg/ml, zvese zvemaawa makumi maviri nemana zvakadziviswa.
Pharmacokinetics
Iyo bioavailability yetriclobendazole yakakwirira.Mushure mekutonga kwemuromo kwe10 mg / kg uremu hwembudzi nemakwai, iyo peak plasma drug yakasvika 15 μg / ml mu24 kusvika maawa 36, uye mazinga eropa etriclobendazole uye metabolites ayo akanga akakwirira.Kukosha kwepamusoro kwemushonga kashanu kusvika makumi maviri kune mamwe benzimidazole anthelmintics, uye kubvisa hafu yehupenyu inenge maawa makumi maviri nemaviri.Triclobendazole inonyanya kusvibiswa mumakwai nemakonzo kune sulfone uye sulfoxide derivatives, iyo inosunga ku albumin uye inoramba iri muplasma kwemazuva anopfuura 7.High plasma concentrations uye kusunga kune plasma albumin inoita seinobatanidzwa nekugara kwenguva refu kwechiito che antifascioli.Mushure memazuva gumi ekushandiswa kwezvinodhaka mumakwai, inenge 95% yemishonga inobudiswa mumarara, 2% inobudiswa mumuguta, uye pasi pe1% inobudiswa mumukaka.
Zviito uye Zvishandiso
Benzimidazole anti-fasciola mushonga.Inonyanya kushandiswa kudzivirira uye kurapwa kweFasciola hepatica chirwere mumombe nemakwai.
Kuita kwakashata
Hapana maitiro akashata akaonekwa kana akashandiswa zvinoenderana nekushandiswa kwakatemwa uye dosage
Zvekungwaririra
(1) Kuremara panguva yekugadzirwa kwemukaka.
(2) Iine muchetura muhove, uye chigaba chemushonga chasara hachifanire kusvibisa tsime remvura.
(3) Vanhu vasingawirirani nemishonga vanofanira kudzivisa kubata ganda uye kufema kana vachiishandisa, kupfeka magirovhosi pavanenge vachitora mishonga, uye kurambidza kudya, kunwa uye kuputa.
(4) Geza maoko mushure mekushandisa
Nguva yekubvisa
56 mazuva emombe nemakwai
Storage
Chengetedza munzvimbo iri pasi pe30 ℃.
Hebei Veyong Pharmaceutical Co., Ltd, yakavambwa muna 2002, iri muShijiazhuang City, Hebei Province, China, padyo neguta guru Beijing.Iye ihombe GMP-yakasimbiswa veterinary drug bhizinesi, ine R&D, kugadzira uye kutengesa kweVeterinary APIs, gadziriro, premixed feed uye feed additives.SeProvincial Technical Center, Veyong yakamisa hurongwa hweR&D hwemishonga mitsva yezvipfuyo, uye ndiyo inozivikanwa pasi rose tekinoroji innovation yakavakirwa bhizinesi rezvipfuyo, kune makumi matanhatu neshanu nyanzvi.Veyong ine mabhesi maviri ekugadzira: Shijiazhuang neOrdos, iyo iyo Shijiazhuang base inovhara nzvimbo ye78,706 m2, ine 13 API zvigadzirwa zvinosanganisira Ivermectin, Eprinomectin, Tiamulin Fumarate, Oxytetracycline hydrochloride ects, uye 11, gadziriro yekugadzira oral poda, mitsara yekugadzira oral. , premix, bolus, mishonga yezvipembenene nemishonga inouraya utachiona, ects.Veyong inopa APIs, anopfuura zana ega- label gadziriro, uye OEM & ODM sevhisi.
Veyong inokoshesa zvikuru manejimendi eEHS(Environment, Health & Safety) system, uye yakawana ISO14001 uye OHSAS18001 zvitupa.Veyong yakanyorwa mumabhizinesi ari kusimukira maindasitiri muHebei Province uye inogona kuve nechokwadi chekuenderera mberi kwezvigadzirwa.
Veyong yakamisa hurongwa hwekutonga kwemhando yakakwana, yakawana chitupa cheISO9001, chitupa cheChina GMP, chitupa cheAustralia APVMA GMP, chitupa cheEthiopia GMP, chitupa cheIvermectin CEP, uye yakapasa ongororo yeUS FDA.Veyong ine timu yehunyanzvi yekunyoresa, kutengesa uye tekinoroji sevhisi, kambani yedu yakawana kuvimba nerutsigiro kubva kune akawanda vatengi nemhando yepamusoro yechigadzirwa, yepamusoro-yemhando yepamusoro-yekutanga kutengesa uye mushure mekutengesa sevhisi, yakakomba uye yesainzi manejimendi.Veyong yaita kushandira pamwe kwenguva refu nemabhizinesi mazhinji anozivikanwa pasi rose emishonga yemhuka ane zvigadzirwa zvinotengeswa kuEurope, South America, Middle East, Africa, Asia, etc. kupfuura nyika makumi matanhatu nematunhu.
