10% Enrofloxacin Jekiseni
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Vhidhiyo
Pharmacological Action
Enrofloxacin ijenti yakakura-yakasiyana-siyana yebhakitiriya yemhuka dzefluoroquinolone.Nezve Escherichia coli, Salmonella, Klebsiella, Brucella, Pasteurella, Actinobacillus pleuropneumoniae, Erysipelas, Proteus, Serratia marcescens, Corynebacterium pyogenes, Porter's sepsis Bacteria, Staphylococcus aureus, Mycoplasmas, Chlamydia, Chlamydia , Chlamydia , Chlamydia , Chlamydia, etc. uye Streptococcus, uye isina simba mhedzisiro pane anaerobic mabhakitiriya.Iine antibacterial effect iri pachena pane mabhakitiriya anonzwa.Iyo inorwisa mabhakitiriya chiito chechigadzirwa ichi kuvharira bhakitiriya DNA gyrase uye kukanganisa bhakitiriya reDNA rekudzokorora, kunyora uye kugadzirisa uye kusanganisa.Utachiona hahukwanisi kukura uye kuberekana sezvazviri uye kufa.
Pharmacokinetics
10% Enrofloxacin Jekiseniinokurumidza uye inotorwa zvachose nejekiseni remumuscular.Iyo bioavailability yechigadzirwa ichi ndeye 91.9% yenguruve uye 82% yemombe dzemukaka.Inoparadzirwa zvakanyanya mumhuka uye inogona kupinda mumatishu zvakanaka.Kunze kwecerebrospinal fluid, huwandu hwezvinodhaka munenge matishu ese akakwirira kupfuura ari muplasma.Chiropa chemetabolism chinonyanya kubvisa ethyl boka re7-piperazine ring kuti ibudise ciprofloxacin, inoteverwa neoxidation uye glucuronic acid binding.Inonyanya kubudiswa kuburikidza neitsvo (kuburikidza nerenal tubular secretion uye glomerular filtration), uye 15% ~ 50% inobudiswa muweti muchimiro chayo chepakutanga.Iyo yekubvisa hafu yehupenyu inosiyana zvakanyanya pakati pemhando dzakasiyana dzemhuka uye dzakasiyana nzira dzekutonga.Kubvisa hafu yeupenyu mushure mejekiseni remumuscular ndeye 5.9 maawa emombe, 9.9 maawa emabhiza, 1.5 kusvika 4.5 maawa emakwai, uye 4.6 maawa enguruve.
Kudyidzana
(1)10% jekiseni Enrofloxacininoshandiswa pamwe chete neaminoglycosides kana broad-spectrum penicillin, iyo ine synergistic effect.
(2) Heavy metal ions yakadai seCa2+, Mg2+, Fe3+ uye Al3+ inogona chelate nechigadzirwa ichi uye inokanganisa kunwa.
(3) Kana yakabatanidzwa ne theophylline uye caffeine, inogona kuderedza plasma protein binding rate, kuwedzera zvisiri izvo kuwanda kwe theophylline uye caffeine muropa, uye kunyange kukonzera zviratidzo zveophylline chepfu.
(4) Ichi chigadzirwa chine mhedzisiro yekuvharisa chiropa chemishonga enzymes, iyo inogona kuderedza chiyero chekuregererwa kwemishonga inonyanya kushandiswa muchiropa uye kuwedzera muropa zvinodhaka.
Basa uye Kushandisa
Fluoroquinolone antibacterial mishonga.Inoshandiswa kune zvirwere zvebhakitiriya uye mycoplasma zvirwere muzvipfuwo uye huku
Dosage uye kutonga
Intramuscular jekiseni: imwe dose, pa 1kg muviri uremu, 0.025ml mombe, hwai, uye nguruve;0.025~0.05ml yembwa, katsi, uye tsuro.Shandisa 1 kusvika 2 kanomwe pazuva kwemazuva maviri kusvika matatu.
Maitiro asina kunaka
(1) Kuderera kwekashwa mumhuka diki, kunokanganisa kukura kwemapfupa uye kukonzera claudication uye kurwadziwa.
(2) Zvinoitwa negadziriro yekugaya zvinosanganisira kurutsa, kurasikirwa nechido, uye manyoka.
(3) Kuita kweganda kunosanganisira erythema, itching, urticaria uye photosensitivity.
(4) Allergic reactions, ataxia, uye pfari zvinomboonekwa mumbwa nekatsi.
Hebei Veyong Pharmaceutical Co., Ltd, yakavambwa muna 2002, iri muShijiazhuang City, Hebei Province, China, padyo neguta guru Beijing.Iye ihombe GMP-yakasimbiswa veterinary drug bhizinesi, ine R&D, kugadzira uye kutengesa kweVeterinary APIs, gadziriro, premixed feed uye feed additives.SeProvincial Technical Center, Veyong yakamisa hurongwa hweR&D hwemishonga mitsva yezvipfuyo, uye ndiyo inozivikanwa pasi rose tekinoroji innovation yakavakirwa bhizinesi rezvipfuyo, kune makumi matanhatu neshanu nyanzvi.Veyong ine mabhesi maviri ekugadzira: Shijiazhuang neOrdos, iyo iyo Shijiazhuang base inovhara nzvimbo ye78,706 m2, ine 13 API zvigadzirwa zvinosanganisira Ivermectin, Eprinomectin, Tiamulin Fumarate, Oxytetracycline hydrochloride ects, uye 11, gadziriro yekugadzira oral poda, mitsara yekugadzira oral. , premix, bolus, mishonga yezvipembenene nemishonga inouraya utachiona, ects.Veyong inopa APIs, anopfuura zana ega- label gadziriro, uye OEM & ODM sevhisi.
Veyong inokoshesa zvikuru manejimendi eEHS(Environment, Health & Safety) system, uye yakawana ISO14001 uye OHSAS18001 zvitupa.Veyong yakanyorwa mumabhizinesi ari kusimukira maindasitiri muHebei Province uye inogona kuve nechokwadi chekuenderera mberi kwezvigadzirwa.
Veyong yakamisa hurongwa hwekutonga kwemhando yakakwana, yakawana chitupa cheISO9001, chitupa cheChina GMP, chitupa cheAustralia APVMA GMP, chitupa cheEthiopia GMP, chitupa cheIvermectin CEP, uye yakapasa ongororo yeUS FDA.Veyong ine timu yehunyanzvi yekunyoresa, kutengesa uye tekinoroji sevhisi, kambani yedu yakawana kuvimba nerutsigiro kubva kune akawanda vatengi nemhando yepamusoro yechigadzirwa, yepamusoro-yemhando yepamusoro-yekutanga kutengesa uye mushure mekutengesa sevhisi, yakakomba uye yesainzi manejimendi.Veyong yaita kushandira pamwe kwenguva refu nemabhizinesi mazhinji anozivikanwa pasi rose emishonga yemhuka ane zvigadzirwa zvinotengeswa kuEurope, South America, Middle East, Africa, Asia, etc. kupfuura nyika makumi matanhatu nematunhu.
