4% Gentamyclin sulphate jekiseni
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Indication
Chitarisiko:Ichi chigadzirwa hachina ruvara kune yero kana yero yakasvibira yakajeka mvura.
Pharmacological chiito:PharmacodynamicGentamycininonzi aminoglycoside antibiotic ine antibacterial effect pane zvakasiyana-siyana zve gram-negative mabhakitiriya (akadai seEscherichia coli, Klebsiella, Proteus, Pseudomonas aeruginosa, Pasteurella, Salmonella, nezvimwewo) uye Staphylococcus aureus (kusanganisira β-lacingstrains-pro).Most cocci (Streptococcus pyogenes, pneumococcus, Streptococcus faecalis, etc.), anaerobic mabhakitiriya (Bacteroides kana Clostridium), Mycobacterium tuberculosis, Rickettsia uye fungi rinopesana nechigadzirwa ichi.
Pharmacokinetics:Kutora kunokurumidza uye kwakakwana mushure mejekiseni re intramuscular.Peak concentrations inosvika mukati me 0.5 kusvika 1 awa.Bioavailability inodarika 90% kune subcutaneous kana intramuscular jekiseni.Inonyanya kubudiswa ne glomerular filtration uye inotora 40% kusvika 80% yedhesi rinoshandiswa.Kubviswa kwehafu yeupenyu mushure mejekiseni remumuscular 1.8 kusvika 3.3 maawa mumabhiza, 2.2 kusvika 2.7 maawa mumhuru, 0.5 kusvika 1.5 maawa mumbwa nekatsi, 1 awa mumhou nenguruve, 1 kusvika 2 maawa mutsuro, uye 2.3 kusvika 3.2 maawa mumakwai, nyati, mombe, uye mbudzi dzomukaka.
Kudyidzana kwezvinodhaka:
(1) Kusanganiswa kweGentamycin ne tetracycline uye erythromycin kunogona kuve nekupikisa.
(2) Mukubatana necephalosporins, dextran, diuretics ine simba (yakadai sefurosemide, nezvimwewo), uye erythromycin, iyo ototoxicity yechigadzirwa ichi inogona kuwedzerwa.
(3) Skeletal muscle relaxants (senge succinylcholine chloride, nezvimwewo) kana zvinodhaka zvine izvi zvinogona kuwedzera neuromuscular blocking effect yeHUMIRA.
Chiito uye kushandiswa
Aminoglycoside antibiotics.Kune Gram-negative uye yakanaka mabhakitiriya zvirwere.
Dosage uye kutonga
(1) Ototoxicity.Inowanzokonzera kukuvadzwa kwevestibular munzeve, iyo inogona kukwidziridzwa nekuunganidzwa kwezvinodhaka zvinoramba zvichiitwa nenzira inoenderana nedosi.
(2) Kusawirirana nevamwe pano neapo.Makati anonyanya kuoma, nguva dzose inogona kukonzera kushungurudza, kurutsa, salivation uye ataxia.
(3) Mishonga yakakwirira inogona kukonzera neuromuscular conduction blockade.Kufa netsaona kunowanzoitika mushure mekuvhiyiwa kwekuvhiya kwembwa nekatsi, kusanganiswa nepenicillin kudzivirira hutachiona.
(4) Inogona kukonzera kudzoreredzwa nephrotoxicity.
Zvekungwaririra
(1) Gentamycin inogona kushandiswa pamwe chete ne β-lactam antibiotics kurapa zvirwere zvakanyanya, asi haipindirani kana yakasanganiswa in vitro.
(2) Mukubatana nepenicillin, chigadzirwa ichi chine synergistic mhedzisiro pane streptococci.
(3) Ine kufema kuora mwoyo uye haifaniri kubayiwa jekiseni netsinga.
(4) Kupesana kunogona kuitika pamwe chete ne tetracycline uye erythromycin.
(5) Kusanganiswa necephalosporins kunogona kuwedzera nephrotoxicity.
Nguva yekubvisa
Nguruve, mombe nehwai kwemazuva makumi mana.
Storage
Yakavharwa uye yakachengetwa munzvimbo inotonhorera ine rima.
Hebei Veyong Pharmaceutical Co., Ltd, yakavambwa muna 2002, iri muShijiazhuang City, Hebei Province, China, padyo neguta guru Beijing.Iye ihombe GMP-yakasimbiswa veterinary drug bhizinesi, ine R&D, kugadzira uye kutengesa kweVeterinary APIs, gadziriro, premixed feed uye feed additives.SeProvincial Technical Center, Veyong yakamisa hurongwa hweR&D hwemishonga mitsva yezvipfuyo, uye ndiyo inozivikanwa pasi rose tekinoroji innovation yakavakirwa bhizinesi rezvipfuyo, kune makumi matanhatu neshanu nyanzvi.Veyong ine mabhesi maviri ekugadzira: Shijiazhuang neOrdos, iyo iyo Shijiazhuang base inovhara nzvimbo ye78,706 m2, ine 13 API zvigadzirwa zvinosanganisira Ivermectin, Eprinomectin, Tiamulin Fumarate, Oxytetracycline hydrochloride ects, uye 11, gadziriro yekugadzira oral poda, mitsara yekugadzira oral. , premix, bolus, mishonga yezvipembenene nemishonga inouraya utachiona, ects.Veyong inopa APIs, anopfuura zana ega- label gadziriro, uye OEM & ODM sevhisi.
Veyong inokoshesa zvikuru manejimendi eEHS(Environment, Health & Safety) system, uye yakawana ISO14001 uye OHSAS18001 zvitupa.Veyong yakanyorwa mumabhizinesi ari kusimukira maindasitiri muHebei Province uye inogona kuve nechokwadi chekuenderera mberi kwezvigadzirwa.
Veyong yakamisa hurongwa hwekutonga kwemhando yakakwana, yakawana chitupa cheISO9001, chitupa cheChina GMP, chitupa cheAustralia APVMA GMP, chitupa cheEthiopia GMP, chitupa cheIvermectin CEP, uye yakapasa ongororo yeUS FDA.Veyong ine timu yehunyanzvi yekunyoresa, kutengesa uye tekinoroji sevhisi, kambani yedu yakawana kuvimba nerutsigiro kubva kune akawanda vatengi nemhando yepamusoro yechigadzirwa, yepamusoro-yemhando yepamusoro-yekutanga kutengesa uye mushure mekutengesa sevhisi, yakakomba uye yesainzi manejimendi.Veyong yaita kushandira pamwe kwenguva refu nemabhizinesi mazhinji anozivikanwa pasi rose emishonga yemhuka ane zvigadzirwa zvinotengeswa kuEurope, South America, Middle East, Africa, Asia, etc. kupfuura nyika makumi matanhatu nematunhu.
