Tildidirosin
.png)
.png)
.png)
.png)
Tildidirosin
Tildipirosin rudzi rutsva rwe semi-synthetic 16-membered ring macrolide antibiotic yemhuka, inova yakabva kune tylosin.
Pharmacological chiito
Iyo antibacterial effect yeTildidirosin yakafanana neyo tylosin, uye ine simba rakasimba rekudzivirira paGram-positive mabhakitiriya uye mamwe mabhakitiriya eGram-negative.Iyo antibacterial mechanism yeTildidirosin yakafanana neye macrolides.Inogona kusanganiswa ne50S subunit yeribosome yehutachiona hwehutachiona kuti inhibit synthesis ye riboprotein peptide maketani, nekudaro kukanganisa kuumbwa kwebhakitiriya mapuroteni.Kubatana kwezvikamu zviviri zvepiperidine zvakasiyana neTildidirosin inosiyanisa nzira yekuita kwechirwere ichi kubva kune tylosin uye tilmicosin, apo 20-piperidine inotungamirirwa mu lumen kuti ivhiringidze kukura kwepeptides nascent.
Nekuti tediroxine ine matatu ekutanga amino mapoka, inogona kugadzira akasiyana mafomu ekuchaja pasi pemamiriro akasiyana epH.Kuwanda kwekubhadharisa chinhu chakakosha kuparadza kunyungudika kwebhakitiriya lipids uye kupinda mukati me membrane yeGram-negative mabhakitiriya, saka bacteriostatic basa reTildidirosin in vitro rinokanganiswa zvakanyanya nepH.Pasi pemamiriro e acidic, boka reamino rinoitwa protonated, zvichiita kuti kuderera kwekuita kwe antibacterial ye tediroxine, asi pasi pemamiriro e-alkaline, ine simba rekudzivirira antibacterial.
Macrolides inhibit secretion ye proinflammatory cytokines, phospholipase basa, uye leukotriene release, uye ine anti-inflammatory effects mu macrophages uye neutrophils.Tediroxine inoderedza kuzvimba vamiriri vanogadzirwa panguva yekumwe kuzvimba kana kushushikana mhinduro.
Antibacterial spectrum
Tildipirosin inoshanda kurwisa mabhakitiriya epathogenic anokonzera zvirwere zvekufema munguruve nemombe (zvakadai sePasteurella multocida, Actinobacillus pleuropneumoniae, Bordetella bronchiseptica, Haemophilus parasuis, Mannheim spp. etc.) basa reantibacterial retilmicosin raive rakakwirira 2-32 nguva kupfuura iyo yetiti-micosin. , uye iyo inorwisa mabhakitiriya inopesana nemudumbu Escherichia coli yaive nani pane tylosin uye tilmicosin.Inonzwawo kune dzimwe mycoplasma strains, spirochetes, brucella, etc. Zvidzidzo zvakaratidza kuti tediroxine ine simba rebacteriostatic effect pa Haemophilus parasuis uye Bordetella bronchiseptica kupfuura florfenicol, asi ine simba bacteriostatic effect pa Actinobacillus pleuropneumoniae uye Pasteurella multocida.Tildipirosin inouraya utachiona kune mamwe mabhakitiriya (akadai seHaemophilus parasuis neActinobacillus pleuropneumoniae), asi ichinyanya kuuraya bhakitiriya kune mamwe mabhakitiriya (akadai sePasteurella multocida).Kune mabhakitiriya emukati, nekuderera kwepH kukosha (kubva ku7.3 kusvika ku6.7), MIC yeTildidirosin yakawedzera, somuenzaniso, MIC yeTildipirosin kurwisana neSalmonella Enteritidis uye Escherichia coli inogona kuwedzera kubva ku2 ~ 8ug / m kusvika 64 ~ 256ug / mL. .Naizvozvo, mhedzisiro yepH shanduko mu vivo inofanirwa kutariswa paunenge uchiitisa in vivo antibacterial test yeTildidirosin.Mukuwedzera, iyo MIC yeTildidirosin inopesana nemhando dzakafanana dzePasteurella multocida yaiva 0.5ug / mL mu serum, iyo yaiva 0.25 nguva yakaderera pane iyo in vitro, iyo inogona kunge yakabatana neserum effect.
Enterococcus-Streptococcus mumombe dzemukaka inopokana zvakanyanya ne tediroxine.Tildipirosin hainzwe Pasteurella multocida uye Mannheimia haemolyticus inotakura mutant majini.Sezvimwechetezvo, mhando dzeM. bovis dzakaitwa genetically mutated kune macrolide antibiotics kusanganisira Tildidirosin.Mamwe marudzi eHaemophilus parasuis akawanikwawo achipokana ne tediroxine.Mycoplasma bovis inogona kukurumidza kuwana kushorwa neTildidirosin, asi nekuda kwekukura zvishoma nezvishoma kweMycoplasma, in vitro susceptibility testing inogona kunonoka kurapwa.Zvidzidzo zvakaratidza kuti domain II (nucleotide 748) uye domain V (Mutations mu nucleotides 2059 uye 2060) inobatanidzwa nekuwedzera kupikisa macrolides.Naizvozvo, kubatwa kweM. bovis kune macrolide mishonga kunogona kukurumidza kuwanikwa nekuongororwa kwema molecular yekuchinja uku.
Content
≥ 98%
Tsanangudzo
Company standard
Hebei Veyong Pharmaceutical Co., Ltd, yakavambwa muna 2002, iri muShijiazhuang City, Hebei Province, China, padyo neguta guru Beijing.Iye ihombe GMP-yakasimbiswa veterinary drug bhizinesi, ine R&D, kugadzira uye kutengesa kweVeterinary APIs, gadziriro, premixed feed uye feed additives.SeProvincial Technical Center, Veyong yakamisa hurongwa hweR&D hwemishonga mitsva yezvipfuyo, uye ndiyo inozivikanwa pasi rose tekinoroji innovation yakavakirwa bhizinesi rezvipfuyo, kune makumi matanhatu neshanu nyanzvi.Veyong ine mabhesi maviri ekugadzira: Shijiazhuang neOrdos, iyo iyo Shijiazhuang base inovhara nzvimbo ye78,706 m2, ine 13 API zvigadzirwa zvinosanganisira Ivermectin, Eprinomectin, Tiamulin Fumarate, Oxytetracycline hydrochloride ects, uye 11, gadziriro yekugadzira oral poda, mitsara yekugadzira oral. , premix, bolus, mishonga yezvipembenene nemishonga inouraya utachiona, ects.Veyong inopa APIs, anopfuura zana ega- label gadziriro, uye OEM & ODM sevhisi.
Veyong inokoshesa zvikuru manejimendi eEHS(Environment, Health & Safety) system, uye yakawana ISO14001 uye OHSAS18001 zvitupa.Veyong yakanyorwa mumabhizinesi ari kusimukira maindasitiri muHebei Province uye inogona kuve nechokwadi chekuenderera mberi kwezvigadzirwa.
Veyong yakamisa hurongwa hwekutonga kwemhando yakakwana, yakawana chitupa cheISO9001, chitupa cheChina GMP, chitupa cheAustralia APVMA GMP, chitupa cheEthiopia GMP, chitupa cheIvermectin CEP, uye yakapasa ongororo yeUS FDA.Veyong ine timu yehunyanzvi yekunyoresa, kutengesa uye tekinoroji sevhisi, kambani yedu yakawana kuvimba nerutsigiro kubva kune akawanda vatengi nemhando yepamusoro yechigadzirwa, yepamusoro-yemhando yepamusoro-yekutanga kutengesa uye mushure mekutengesa sevhisi, yakakomba uye yesainzi manejimendi.Veyong yaita kushandira pamwe kwenguva refu nemabhizinesi mazhinji anozivikanwa pasi rose emishonga yemhuka ane zvigadzirwa zvinotengeswa kuEurope, South America, Middle East, Africa, Asia, etc. kupfuura nyika makumi matanhatu nematunhu.
