0.2% IVERMECTIN DRENCH
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Pharmacological chiito
Ivermectinkunyanya ine yakanaka anthelmintic mhedzisiro pane nematodes uye pamusoro arthropods in vivo.Iyo anthelmintic mechanism ndeyekusimudzira kuburitswa kwe γ-aminobutyric acid (GABA) kubva kune presynaptic neurons, nekudaro kuvhura nzira dzeGABA-mediated chloride.Ivermectin inosarudza uye yakakwirira-yakabatana ye glutamate-mediated chloride channels iri pedyo neGABA-mediated sites mu invertebrate nerve uye masero emumhasuru, nokudaro ichikanganisa kutapurirwa kwechiratidzo pakati pemitsipa yeuromuscular uye kuzorora uye kuomesa chirwere, zvichiita kuti pave nekufa kweparasite kana kudzingwa kubva muviri.The inhibitory interneurons uye excitatory motoneurons yeC. elegans ndidzo nzvimbo dzadzo dzekuita, nepo nzvimbo yekuita arthropods iri neuromuscular junction.Inoshandawo pakurwisa honye, semagonye, mite, uye inda.munhu mukuru Coronaria dentata uye utachiona husina kukura munguruve, inoshandawo zvakanyanya kuTrichinella spiralis muura (haishandi kune intramuscular Trichinella spiralis), uye zvakare ine yakanaka kudzora inda dzeropa renguruve uye Sarcoptes scabiei.Haishande pakurwisa trematodes uye tapeworms.
Pharmacokinetics
Iyo pharmacokinetics yeivermectinzvinosiyana zvakanyanya zvichienderana nerudzi rwemhuka, fomu reyero, uye nzira yekutonga.Iyo bioavailability ye subcutaneous jekiseni yakakwirira kupfuura iyo yekutonga nemuromo, asi nemuromo kutonga kunowedzera kukurumidza kutorwa kupfuura subcutaneous jekiseni.Mushure mekutora, inogona kugoverwa zvakanaka kune akawanda tishu, asi hazvisi nyore kupinda mu cerebrospinal fluid.Iyo inoratidzika vhoriyamu yekugovera mumakwai nenguruve ndeye 4.6 uye 4 L / kg, zvichiteerana.Iine hafu yakareba yehupenyu mumhuka dzakawanda, 2 kusvika ku7 uye 0.5 mazuva mumakwai nenguruve, maererano.Ichi chigadzirwa chinogadziriswa muchiropa, kunyanya hydroxylated mumakwai, uye kunyanya methylated munguruve.Inonyanya kubudiswa mutsvina uye isingasviki 5% inobudiswa isina kuchinjwa kana semetabolites muweti.Mumadhamu anoyamwisa, 5% yedhesi inobudiswa mumukaka.
Kudyidzana Kwezvinodhaka
Kushandiswa pamwe chete nediethylcarbamazine kunogona kuunza encephalopathy yakaoma kana inouraya.
Chiito uye kushandiswa
Macrolide antiparasite mishonga.Inoshandiswa kudzora nematode, acariasis uye tupukanana zvirwere mumakwai nenguruve.
Dosage uye kutonga
Oral: imwe dosi, 0.1 ml yehwai uye 0.15 ml yenguruve pa1 kg yehuremu hwemuviri.
Maitiro asina kunaka
Hapana maitiro akashata akacherechedzwa kana akashandiswa zvinoenderana neyakatsanangurwa mashandisiro uye dosage.
Zvekungwaririra
(1) Inopikiswa panguva yekuyamwisa.
(2) Inofanira kushandiswa nokungwarira panguruve mukati memazuva 45 okutanga enhumbu.
(3) Ivermectin shrimp, hove uye zvipenyu zvemumvura zvine muchetura zvakanyanya, uye kurongedza uye midziyo yemishonga inosara haifanire kusvibisa matsime emvura.
Nguva yekubvisa: 35 mazuva emakwai uye 28 mazuva enguruve.
Nguva yekubvisa
35 mazuva emakwai uye mazuva makumi maviri nemasere enguruve.
Hebei Veyong Pharmaceutical Co., Ltd, yakavambwa muna 2002, iri muShijiazhuang City, Hebei Province, China, padyo neguta guru Beijing.Iye ihombe GMP-yakasimbiswa veterinary drug bhizinesi, ine R&D, kugadzira uye kutengesa kweVeterinary APIs, gadziriro, premixed feed uye feed additives.SeProvincial Technical Center, Veyong yakamisa hurongwa hweR&D hwemishonga mitsva yezvipfuyo, uye ndiyo inozivikanwa pasi rose tekinoroji innovation yakavakirwa bhizinesi rezvipfuyo, kune makumi matanhatu neshanu nyanzvi.Veyong ine mabhesi maviri ekugadzira: Shijiazhuang neOrdos, iyo iyo Shijiazhuang base inovhara nzvimbo ye78,706 m2, ine 13 API zvigadzirwa zvinosanganisira Ivermectin, Eprinomectin, Tiamulin Fumarate, Oxytetracycline hydrochloride ects, uye 11, gadziriro yekugadzira oral poda, mitsara yekugadzira oral. , premix, bolus, mishonga yezvipembenene nemishonga inouraya utachiona, ects.Veyong inopa APIs, anopfuura zana ega- label gadziriro, uye OEM & ODM sevhisi.
Veyong inokoshesa zvikuru manejimendi eEHS(Environment, Health & Safety) system, uye yakawana ISO14001 uye OHSAS18001 zvitupa.Veyong yakanyorwa mumabhizinesi ari kusimukira maindasitiri muHebei Province uye inogona kuve nechokwadi chekuenderera mberi kwezvigadzirwa.
Veyong yakamisa hurongwa hwekutonga kwemhando yakakwana, yakawana chitupa cheISO9001, chitupa cheChina GMP, chitupa cheAustralia APVMA GMP, chitupa cheEthiopia GMP, chitupa cheIvermectin CEP, uye yakapasa ongororo yeUS FDA.Veyong ine timu yehunyanzvi yekunyoresa, kutengesa uye tekinoroji sevhisi, kambani yedu yakawana kuvimba nerutsigiro kubva kune akawanda vatengi nemhando yepamusoro yechigadzirwa, yepamusoro-yemhando yepamusoro-yekutanga kutengesa uye mushure mekutengesa sevhisi, yakakomba uye yesainzi manejimendi.Veyong yaita kushandira pamwe kwenguva refu nemabhizinesi mazhinji anozivikanwa pasi rose emishonga yemhuka ane zvigadzirwa zvinotengeswa kuEurope, South America, Middle East, Africa, Asia, etc. kupfuura nyika makumi matanhatu nematunhu.
